Answer:
The H.I.P.P.O. acronym stands for Habitat Destruction, Invasive Species, Pollution, Population growth, and Overharvesting. Without further information about the specific GLTs (I assume you are referring to some kind of animal), it is difficult to determine which two factors are affecting them the most. However, in general, habitat destruction and population growth tend to be the most significant factors affecting many species' survival, as they can lead to fragmentation and loss of habitat, reduced resources, and increased competition. Invasive species and pollution can also have a severe impact on certain species, depending on their ecology and susceptibility. Overharvesting can be a significant problem for species that are commercially valuable, but it may not apply to all species.