Females are usually less affected by sex-linked disorders compared to males. This is because sex-linked disorders are caused by mutations or abnormalities in the genes located on the sex chromosomes, which are the X and Y chromosomes. Females have two copies of the X chromosome, while males have one X and one Y chromosome.
In most cases of sex-linked disorders, the affected gene is located on the X chromosome. Males have only one X chromosome, so if they inherit a mutated X chromosome, they will exhibit the disorder. Females, on the other hand, have two X chromosomes, so even if one X chromosome carries the mutated gene, the other X chromosome may have a normal copy of the gene that can compensate for the mutated one. This means that females are less likely to exhibit the disorder or may exhibit a milder form of the disorder than males.
However, there are some exceptions to this general rule. In some cases of sex-linked disorders, the severity of the disorder depends on the number of mutated X chromosomes that a female has. For example, in cases of X-linked dominant disorders, a female with one mutated X chromosome may exhibit the disorder, while a male with one mutated X chromosome is more likely to die before birth.
Overall, females are usually less affected by sex-linked disorders compared to males due to having two X chromosomes, but the severity of the disorder can vary depending on the specific type of sex-linked disorder and the number of mutated X chromosomes that a female has.