Answer: There are many side effects of tricyclic antidepressants, such as sweating issues (excessive sweating, mainly at night time). This will happen because inhibited reuptake of norepinephrine, leads to the stimulation of peripheral adrenergic receptors. Also, another side effect may be a dry mouth because the effects of these drugs can change the way your mouth may function on the salivary glands, along with perception of oral dryness.