Question

Protein Y has three binding sites for the same ligand and has a Hill coefficient of 2.35. We can therefore say that ligand binding to protein Y is: a. Is fully cooperative. b. Dominated by electrostatic interactions. c. Is negatively cooperative. d. Is positively cooperative. e. Is non-cooperative.

Answer 1

Step-by-step explanation:

d. Is positively cooperative.

The Hill coefficient describes the cooperativity of ligand binding to a protein. A Hill coefficient greater than 1 indicates positive cooperativity, meaning that as one ligand binds, it increases the affinity for the remaining binding sites, and the binding becomes progressively easier. Protein Y has a Hill coefficient of 2.35, which is greater than 1, therefore, the ligand binding to protein Y is positively cooperative.

Answer 2

d. Is positively cooperative.

A Hill coefficient greater than 1 indicates positive cooperativity, meaning that the binding of one ligand molecule increases the binding affinity of the remaining binding sites. Since protein Y has a Hill coefficient of 2.35, it demonstrates strong positive cooperativity.