Answer:
Step-by-step explanation:
Sickle cell trait is an autosomal recessive genetic disorder caused by a mutation in the HBB gene that codes for the beta-globin subunit of hemoglobin. A person with sickle cell trait inherits one normal copy and one mutated copy of the HBB gene, while a person with sickle cell anemia inherits two copies of the mutated gene.
The probability of their child having sickle cell trait, normal, or sickle cell anemia can be calculated using Punnett square analysis:
HbA (normal) HbS (sickle cell trait)
HbA HbA HbA (normal) HbA HbS (sickle cell trait)
HbS HbA HbS (sickle cell trait) HbS HbS (sickle cell anemia)
a) The probability of the child having sickle cell trait (HbA HbS) is 50%.
b) The probability of the child being normal (HbA HbA) is 25%.
c) The probability of the child having sickle cell anemia (HbS HbS) is 25%.
No, the sickle cell trait would not be transmitted to the recipient through a blood transfusion. Sickle cell trait is not contagious and cannot be transmitted through blood transfusions, organ transplants, or other forms of casual contact. The transfused blood will carry the donor's hemoglobin, but it will not change the recipient's genetic makeup or cause them to develop sickle cell trait. However, if the recipient has a child with a partner who has sickle cell trait or sickle cell anemia, there is a chance that their child may inherit the disorder.