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Process by which the weak bonds that collectively maintain the native shape of the apoenzyme are broken.

Causes extreme distortion of the enzymes shape and prevents the substrate from attaching to the active site.
This blocks metabolic reactions and thereby can lead to cell death. Low or high pH or certain chemicals (heavy metals, alcohol) are also denaturing agents.

User Aurelius
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Answer: Denaturation

User Ikaushan
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