It is difficult to predict exactly how the absence of the Missouri Compromise would have affected the indigenous peoples of the Northwest, as the issue of slavery was primarily a concern of the United States government and white settlers, rather than Native American nations.
However, it is possible that the expansion of slavery into the Northwest could have led to increased conflicts between white settlers and Native American nations over land and resources. Additionally, the presence of slavery in the Northwest may have further entrenched the racist and discriminatory attitudes of white settlers towards Native Americans, as they would have viewed them as an inferior race fit for subjugation and enslavement.
It is also worth noting that the Missouri Compromise was part of a larger political struggle over the balance of power between free and slave states in the United States, and its absence may have had significant implications for the nation's political and social landscape in the decades leading up to the Civil War.
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