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A water-soluble hormone would most likely bind to which of the following membrane proteins?

a) G protein-coupled receptor
b) Ion channel
c) Receptor tyrosine kinase
d) Steroid hormone receptor

User Aviw
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Final answer:

A water-soluble hormone binds to a G protein-coupled receptor, as these hormones cannot pass through the cell membrane. The receptor activates a G-protein and triggers an intracellular signaling cascade.

Step-by-step explanation:

A water-soluble hormone would most likely bind to a G protein-coupled receptor (GPCR). Water-soluble or hydrophilic hormones are unable to pass through the lipid bilayer of a cell membrane due to their polarity and therefore require a transmembrane receptor to initiate an intracellular signal. The binding of a water-soluble hormone to the extracellular domain of a GPCR activates an associated G-protein, which in turn may activate other proteins including enzymes or ion channels. This leads to a cascade of intracellular events that carries out the hormone's message inside the cell. GPCR is the interface where extracellular hormones signal to intracellular second messengers such as cyclic AMP (cAMP).

User Babu Swami
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