Final answer:
Alois Alzheimer did observe amyloid plaques and neurofibrillary tangles in the brain of his patients around 100 years ago, making the statement false.
Step-by-step explanation:
The statement that Alois Alzheimer could not and did not observe amyloid plaques and neurofibrillary tangles about 100 years ago in his postmortem analysis due to technological limitations is false. In fact, Alzheimer and his colleagues were able to identify abnormal clumps and tangled brain fibers in the brain of his patients—now known as amyloid plaques and neurofibrillary tangles, respectively—a hallmark in the diagnosis of Alzheimer's disease. These discoveries were documented in his report published in 1911.