Question

A skin transplantation experiment was performed in a laboratory. During the experiment, skin grafts were transplanted between MHC-identical mice. The skin grafts will be rejected by?

Female recipients with grafts from female donors
Male recipients with grafts from female donors
Male recipients with grafts from male donors
Female recipients with grafts from male donors
All male and female animals

Answer 1

Skin grafts transplanted between MHC-identical mice will be rejected by all male and female animals due to the presence of other genetic factors contributing to the immune system's recognition of the transplanted tissue as foreign.

Step-by-step explanation:

In a skin transplantation experiment performed in a laboratory, where skin grafts were transplanted between MHC-identical mice, the skin grafts will be rejected by all male and female animals. This is because while MHC matching significantly reduces the risk of rejection,

there are still other genetic factors that can lead to the recipient's immune system recognizing the transplanted tissue as foreign. The presence of foreign MHC molecules can stimulate a cytotoxic T cell response, leading to transplant rejection.

Additionally, immunosuppressive therapy is often required for transplant recipients to prevent rejection, which can make them more susceptible to infections and malignancies.