Question

Skeletal muscle develops from myoblasts that migrate throughout the embryo. During migration, myoblasts receive biochemical signals and cues from the surrounding connective tissue. In the head region of the embryo, connective tissue is primarily of neural crest origin. In the limbs, the connective tissue is derived from lateral plate parietal (somatic) mesoderm. The cellular and molecular mechanisms that pattern the size, shape, and attachments of muscles are largely unknown. None of the other cells or tissues are known to regulate the patterning of skeletal muscles during embryonic development. Which cells or tissues are known to regulate the patterning of skeletal muscles during embryonic development?

1) Myoblasts
2) Neural crest cells
3) Lateral plate parietal mesoderm
4) Other cells or tissues

Answer 1

Connective tissues regulate the patterning of skeletal muscles during embryonic development, with myoblasts and different mesodermal origins involved in the head and limbs.

Step-by-step explanation:

The tissues known to regulate the patterning of skeletal muscles during embryonic development are myoblasts derived from mesoderm and the surrounding connective tissue. In the head region, the connective tissue is mainly of neural crest origin, while in the limbs, it is from the lateral plate parietal mesoderm. Somites, which are reorganized mesodermal structures, differentiate into myoblasts that migrate and fuse to form multinucleate myotubes, the precursors to skeletal muscle fibers.