Final answer:
The largest city in Bolivia on the Pirai River is Santa Cruz de la Sierra, an important economic center with substantial population growth, much like other large cities in South America.
Step-by-step explanation:
The largest city in Bolivia on the Pirai River is Santa Cruz de la Sierra. Santa Cruz is a bustling economic hub, characterized by rapid growth and development, which contrasts with the more subsistence-based lifestyle around Lake Titicaca as described in the provided LibreTexts™ information. While the information mentions Potosí, which was historically important due to silver mining and is still notable for its high elevation, Santa Cruz has overtaken it to become the largest city in Bolivia.
In terms of cultural and economic significance, cities like Rio de Janeiro in Brazil highlight the importance of urban centers for tourism and business. As in the case of Brazil’s major cities, Bolivia’s Santa Cruz also exhibits a pattern of population growth and urban expansion from internal migration, emphasizing the shift from rural to urban settings within the region.