Final answer:
The largest port in Germany and second largest in Europe, situated on the Elbe River, is Hamburg. This port underscores Germany's strong economy and its key role in global trade.
Step-by-step explanation:
The city in Germany that is the largest port, the second largest in Europe, and lies on the Elbe River in Hamburg. As Europe's second-busiest port, it serves as a major hub for trade with goods being transported through its waters to and from places all over the continent. Hamburg's port is a testament to Germany's robust economy and its strategic position in global trade, especially considering the country's strong focus on manufacturing and exports such as automobiles, machinery, metals, and chemical goods.