Final answer:
The island nation located in the Caribbean that lies east of St. Kitts and Nevis and north of Guadeloupe is Antigua and Barbuda, part of the Leeward Islands in the Lesser Antilles.
Step-by-step explanation:
The country that is an island nation in the Caribbean, part of the Leeward Islands in the Lesser Antilles, lying east of St. Kitts and Nevis and north of Guadeloupe is Antigua and Barbuda. The Lesser Antilles is a long arc of small islands in the eastern Caribbean Sea and includes the Leeward Islands where Antigua and Barbuda is located. This region, along with the Greater Antilles and the Bahamas, was heavily influenced by European colonizers, particularly during the time when the Caribbean was a focal point for colonial expansion, trade, and conflict among European powers.