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Describe the experiment done in pregnant mice that produced an obesity phenotype in mice pups despite the fact that all pups were 99.99

User Avhi
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Final answer:

An experiment on pregnant mice that leads to obesity phenotypes in offspring, despite genetic similarity, involves altering gene expression through the maternal diet. This highlights the role of the intrauterine environment and epigenetics in the development of obesity and metabolic disorders.

Step-by-step explanation:

The experiment in question likely refers to epigenetic studies conducted on pregnant mice to understand the impacts of maternal factors on the development of obesity phenotypes in offspring. A notable experiment is one where pregnant mice are fed a high-fat diet, which alters the epigenetic expression of genes in their pups leading to obesity and metabolic disorders, despite the pups all having identical or nearly identical genetics (99.99% genetic similarity). This occurs due to changes in the expression of genes involved in metabolism and fat storage as a result of the maternal environment—the prenatal exposure to a high-fat diet—rather than changes in the underlying DNA sequence itself.

These studies illustrate the significant role of maternal diet and the intrauterine environment in shaping the health and metabolic profiles of offspring. The obesity phenotype develops as a result of epigenetic modifications, such as DNA methylation and histone modification, which can lead to altered gene expression patterns throughout the life of the mice pups. This research is crucial for understanding the mechanisms behind the intergenerational transmission of obesity and metabolic diseases.

User Amunnelly
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