Final answer:
Irisin is hypothesized to be a key mediator in the beneficial effects of exercise on synaptic plasticity and memory in Alzheimer's Disease (AD) models, playing a vital role in enhancing brain health and cognitive functions compromised in AD.
Step-by-step explanation:
The hypothesis regarding the role of irisin in the beneficial effects of exercise on synaptic plasticity and memory in Alzheimer's Disease (AD) models is that irisin is a key mediator of these effects. Exercise-induced release of irisin is believed to enhance brain health and cognitive functions by promoting synaptic plasticity and memory enhancement. This hypothesis is supported by research indicating that physical activity leads to increased levels of irisin, which in turn may support memory and learning by improving neural connections in the brain, mechanisms that are compromised in AD.