Final answer:
In a musical composition, if the key changes 4 times, it usually means there are 4 main keys, one for each change, including the original key.
Step-by-step explanation:
If a piece of music changes key 4 times, that typically means there are 5 main keys in total. Each time the music changes to a different key it indicates the beginning of a new key. However, if the question implies the original key is included in the count of changes, then the piece would have 4 main keys, one for each key change. The correct answer, assuming we count the original key and each change as distinct, is D) Four.