Final answer:
Tigecycline is the tetracycline derivative with a broad antimicrobial spectrum, targeting Gram-positive, Gram-negative, anaerobes, and MDR strains, and groups like Doxycycline and Minocycline, it binds to the 30S ribosomal subunit to inhibit protein synthesis.
Step-by-step explanation:
The tetracycline derivative that has a broad spectrum of antimicrobial activity, including Gram-positive, Gram-negative bacteria, anaerobes, and multi-drug resistant (MDR) strains, and inhibits protein synthesis by binding to the 30S ribosomal subunit is Tigecycline. Tigecycline is a derivative of tetracycline, like doxycycline and minocycline, but it is specifically designed to overcome the resistance mechanisms that limit the effectiveness of older tetracyclines. Although doxycycline and minocycline also target the 30s subunit and have broad-spectrum activity, Tigecycline is the correct answer due to its broader spectrum and efficacy against MDR strains.