Final answer:
Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.
Step-by-step explanation:
Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.
- Aminoglycosides are large, highly polar antibacterial drugs that bind to the 30S ribosomal subunit, impairing the proofreading ability and causing mismatches between codons and anticodons.
- Macrolides such as erythromycin, azithromycin, and clarithromycin bind to the 50S ribosomal subunit and prevent peptide bond formation, stopping protein synthesis.
- Sulfonamides such as sulfamethoxazole and trimethoprim interfere with bacterial folic acid synthesis as antimetabolites.