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3 agents that denature proteins or attach to their active site to prevent substrate from interacting:

a) Aminoglycosides, Macrolides, Sulfonamides
b) Beta-lactams, Glycopeptides, Rifamycins
c) Quinolones, Nitrofurans, Isoniazid
d) Echinocandins, Azoles, Allylamines

1 Answer

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Final answer:

Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.

Step-by-step explanation:

Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.

  • Aminoglycosides are large, highly polar antibacterial drugs that bind to the 30S ribosomal subunit, impairing the proofreading ability and causing mismatches between codons and anticodons.
  • Macrolides such as erythromycin, azithromycin, and clarithromycin bind to the 50S ribosomal subunit and prevent peptide bond formation, stopping protein synthesis.
  • Sulfonamides such as sulfamethoxazole and trimethoprim interfere with bacterial folic acid synthesis as antimetabolites.

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