Question

Mark correct statements combination:

a) sartans antagonize AT1 receptors.
b) benzodiazepines antagonize GABA receptors.
c) antiparkinsonics antagonize D2 receptors.
d) opioids antagonize 5-HT3 receptors.

Answer 1

Statement (a) is correct as sartans antagonize AT1 receptors. Statements (b), (c), and (d) are incorrect because benzodiazepines act as GABA agonists, most antiparkinsonics are dopamine agonists, and opioids primarily target opioid receptors without antagonizing 5-HT3 receptors.

Step-by-step explanation:

The correct statements in regard to how certain drugs interact with receptors are marked by their ability to either mimic or block the normal neurotransmitter effects.

• Sartans like losartan and valsartan are indeed antagonists that bind to AT1 receptors on blood vessels and block the effects of angiotensin II, leading to dilation of blood vessels and a reduction in blood pressure. Therefore, (a) is a correct statement.
• Benzodiazepines like diazepam and alprazolam do not antagonize GABA receptors but rather act as agonists, enhancing the inhibitory effects of GABA and inducing sedation and anxiolytic effects. Hence, (b) is incorrect.
• Antiparkinsonics do not typically antagonize D2 receptors; drugs like levodopa act as dopamine agonists to increase dopaminergic activity in the brain, thereby reducing the symptoms of Parkinson's disease. (c) is incorrect.
• Opioids like morphine and codeine primarily target opioid receptors to exert their analgesic effects and do not antagonize 5-HT3 receptors. As such, (d) is incorrect.