Question

A 60-year-old woman presents to the emergency room with a progressive downward course over the past 6 months characterized by behavioral disinhibition, emotional lability, severe naming and word-finding difficulties, hyperorality, stubbornness, inability to plan, and poor judgment. Autopsy of this patient's brain would most likely reveal:

A. Hirano bodies
B. Pick's inclusion bodies and gliosis
C. Lewy bodies
D. Neurofibrillary plaques and tangles
E. Severe white matter demyelination

Answer 1

The autopsy of the patient's brain would most likely reveal Pick's inclusion bodies and gliosis, indicating a diagnosis of frontotemporal dementia (FTD).

Step-by-step explanation:

The symptoms described in the patient's case, including behavioral disinhibition, emotional lability, severe naming and word-finding difficulties, hyperorality, stubbornness, inability to plan, and poor judgment, are consistent with the diagnosis of frontotemporal dementia (FTD). Autopsy of the patient's brain would most likely reveal B. Pick's inclusion bodies and gliosis. Pick's disease is a subtype of FTD characterized by abnormal clumps called Pick bodies that are found in the nerve cells of the frontal and temporal lobes of the brain.