Final answer:
The dangerous combination mentioned in the options is C. MAOI-meperidine. The interaction between MAOIs and meperidine can lead to serotonin syndrome, a potentially fatal condition.
Step-by-step explanation:
Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs that reduce the breakdown of neurotransmitters by inhibiting the enzyme monoamine oxidase. This leads to an increase in the levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. MAOIs can have serious, sometimes fatal interactions with certain foods and drugs.
Among the options provided, the combination of an MAOI with meperidine is particularly dangerous. Meperidine, also known as Demerol, is a synthetic opioid pain medication. When combined with MAOIs, it can lead to a severe and potentially lethal interaction called serotonin syndrome. This syndrome is a result of excessive amounts of serotonin accumulating in the brain, leading to symptoms such as confusion, fever, shivering, high blood pressure, muscle rigidity, and in severe cases, seizures or death.
Therefore, the correct answer to this question is C. MAOI-meperidine, which represents a dangerous drug combination that should be avoided due to the risk of serotonin syndrome.