Final answer:
Two factors that affect the rate and extent of medication distribution are plasma protein binding and the physicochemical properties of the drug.
Step-by-step explanation:
There are several factors that affect the rate and extent of medication distribution. Two important factors are plasma protein binding and physicochemical properties of the drug. Plasma protein binding refers to the binding of drugs to proteins in the blood, primarily albumin. This binding can affect the effectiveness of the drug by slowing down its distribution to the tissues and reducing its clearance from the body. It can also result in drug-drug interactions if different drugs compete for the same binding site on albumin. The physicochemical properties of the drug, such as its solubility and hydrophobicity, can also influence how it is distributed in the body. For example, hydrophobic drugs may have poor solubility and struggle to cross the cell membrane, while hydrophilic drugs may have poor stability and a short half-life in the bloodstream.