Final answer:
During times of stress, the release of cortisone is caused by the activation of the hypothalamic-pituitary-adrenal (HPA) axis. Corticotropin-releasing factor released by the hypothalamus stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn activates the adrenal glands to secrete cortisol.
Step-by-step explanation:
In times of stress, the release of cortisone is caused by the activation of the hypothalamic-pituitary-adrenal (HPA) axis. When a person perceives something as stressful, the hypothalamus releases corticotropin-releasing factor, which then stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then activates the adrenal glands to secrete cortisol, also known as cortisone, into the bloodstream.