Final answer:
Lady Macbeth is indeed troubled by her sinful deeds by Act V, leading to guilt-induced restlessness and a psychological breakdown.
Step-by-step explanation:
By Act V of Macbeth, it is true that Lady Macbeth cannot rest because she is troubled by all her sinful deeds. The overwhelming guilt stemming from the actions she has taken part in, including the orchestration of King Duncan's murder, leads to her restless state and eventual mental breakdown. Her guilt manifests through sleepwalking and obsessive hand-washing, attempting to cleanse herself of the blood—both literal and metaphorical—that stains her conscience.