Final answer:
GABA, or γ-aminobutyric acid, is an inhibitory neurotransmitter in the central nervous system. It suppresses seizure activity, decreases anxiety, and is potentiated by topiramate. Gabapentin also has activity at GABA receptors despite the incorrect answer choice given.
Step-by-step explanation:
GABA, or γ-aminobutyric acid, is an inhibitory neurotransmitter in the central nervous system. It plays a role in regulating neuronal excitability and maintaining the balance between excitation and inhibition in the brain. Regarding the answer choices provided: A. GABA is thought to suppress seizure activity - This is true. GABA acts to inhibit the firing of neurons, reducing their excitability and helping to suppress seizure activity. B. GABA is thought to exacerbate mania - This is not true. GABA deficiencies have been associated with certain psychiatric conditions, including anxiety and depression, but there is no evidence to suggest that it exacerbates mania. C. GABA is thought to decrease anxiety - This is true. GABA has calming effects on the brain and is often targeted by medications used to treat anxiety and related disorders. D. GABA-A activity is potentiated by topiramate - This is true. Topiramate is an anticonvulsant medication that enhances the activity of GABA-A receptors, increasing GABAergic neurotransmission. E. Gabapentin has no activity at the GABA receptors or transporter - This is not true. Gabapentin acts on GABA receptors and is believed to enhance GABAergic neurotransmission.