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Which of the following is true regarding norepinephrine (NE) and/or the locus ceruleus?

A. NE is synthesized in the locus ceruleus
B. Dopamine is synthesized in the locus ceruleus, NE in the dorsal raphe nuclei
C. Acetylcholine is synthesized with NE in the substantia nigra
D. 5-HT is synthesized in the locus ceruleus
E. The locus ceruleus is the site of the formation of serotonin

User Fenton
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Final answer:

The statement that NE is synthesized in the locus ceruleus is correct. The locus ceruleus is the primary source of norepinephrine in the brain and is associated with stress responses and arousal.

Step-by-step explanation:

The locus ceruleus (LC) is a structure in the brainstem that contains the largest number of noradrenergic neurons in the brain, which release NE throughout the central nervous system in response to stimuli. This system plays a significant role in stress response, arousal, and vigilance. Synthesis of dopamine occurs primarily in the substantia nigra and the ventral tegmental area (VTA), both of which are involved in movement, cognition, reward, and addictive behaviors. Serotonin (5-HT) synthesis mainly takes place in the dorsal raphe nucleus (DRN) and median raphe nucleus (MRN), with extensive serotonergic projections throughout the brain, impacting cognition and mood.

User Mittenchops
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