Final answer:
The false statement regarding tricyclic antidepressants (TCAs) is that methylphenidate will decrease TCA levels, as this is not a known effect of methylphenidate.
Step-by-step explanation:
The statement that is false regarding tricyclic antidepressants (TCAs) is: C. Methylphenidate will decrease TCA levels. Tricyclic antidepressants, such as imipramine and amitriptyline, are widely used in the treatment of major depression. They have a structure that includes a middle ring which prevents the conjugation seen in phenothiazines, contributing to their unique antidepressant effects. TCAs are known to have strong anticholinergic effects and can have adverse cardiac effects, which are well-documented side effects of this class of medications. Cigarette smoking has been shown to decrease TCA levels due to the induction of liver enzymes that metabolize TCAs more rapidly. Therefore, C is the false statement, as methylphenidate, which is a central nervous system stimulant, does not have a known effect of decreasing TCA levels. Instead, other medications such as clozapine could potentially increase TCA levels by inhibiting their metabolism.