Final answer:
The major differences between late australopithecines and early Homo are in their skull morphology.
Step-by-step explanation:
A major difference between late australopithecines and early Homo is their skull morphology. Late australopithecines, such as Australopithecus afarensis, had smaller skulls with a sloped forehead, larger teeth, and a prominent jaw, resembling that of modern humans but with distinct differences. On the other hand, early Homo species, like Homo erectus, had bigger jaws and teeth, a sloping forehead, and a relatively small brain. They also had a sagittal keel, indicating a small raised ridge on top of the skull, and their feet had human-like arches and ankles.