Final answer:
The correct answer to the question is C. Hypoglycemia, as it is not a serious adverse effect of long-term oral glucocorticoid therapy. Instead, glucocorticoids usually increase blood glucose levels.
Step-by-step explanation:
The question pertains to the serious adverse effects of long-term oral glucocorticoid therapy. Checking the list provided for which effect is not typically associated with long-term use of this treatment:
- Adrenal suppression is indeed a serious adverse effect as the long-term use of glucocorticoids can suppress the hypothalamic-pituitary-adrenal (HPA) axis.
- Osteoporosis is also a known serious effect, as the therapy can lead to decreased bone density and increased fracture risk.
- Peptic ulcer disease can occur due to the therapy's effect of increasing stomach acid and decreasing the protective mucus lining.
- However, hypoglycemia (low blood glucose levels) is not a typical serious adverse effect of this therapy; in fact, glucocorticoids generally increase blood glucose levels and the risk of hyperglycemia.
Therefore, the correct answer is C. Hypoglycemia.