Final answer:
The critical adverse reaction watched for when giving statins is myopathy, potentially leading to rhabdomyolysis, monitored through the creatine kinase (CK) lab test. Statins act as inhibitors of HMG-CoA reductase to reduce cholesterol levels.
Step-by-step explanation:
When giving statins, such as Atorvastatin (Lipitor) and Rosuvastatin (Crestor), a critical adverse reaction we watch for is myopathy, which can sometimes lead to a more serious condition called rhabdomyolysis. To monitor for these conditions, we look at a specific lab test that measures the levels of creatine kinase (CK), which if elevated, indicates muscle damage. Statins are HMG-CoA reductase inhibitors, the enzyme that synthesizes cholesterol from lipids in the body. By inhibiting this enzyme, the levels of cholesterol synthesized in the body can be reduced. Regular monitoring of liver function tests is also recommended, as statins have the potential to cause liver enzyme elevations, indicating hepatotoxicity.