Final answer:
Age is a significant non-modifiable risk factor for the development of cardiovascular disease, alongside other non-modifiable factors such as gender and genetics.
Step-by-step explanation:
Certain factors place us at risk for development of cardiovascular disease. These factors can be broadly categorized as modifiable and non-modifiable. Non-modifiable risk factors are those that cannot be changed or altered by an individual. Age, gender, and genetics are examples of non-modifiable risk factors. Among these, age is the most significant non-modifiable risk factor, as the likelihood of developing cardiovascular diseases increases with each passing decade of life. Having a family history of cardiovascular disease also substantially raises the risk, due to the genetic component that is inherent and can't be modified.