Final answer:
Alcohol abuse can lead to a deficiency in Vitamin B1 (thiamine), potentially causing Wernicke's encephalopathy, which is characterized by nervous system defects.
Step-by-step explanation:
Alcohol abuse can lead to a deficiency in Vitamin B1, also known as thiamine, which can potentially cause Wernicke's encephalopathy. Thiamine deficiency can result in a condition called 'Beri-Beri', which is characterized by various nervous system defects. Wernicke's encephalopathy is specifically associated with acute thiamine deficiency in alcoholics.