Final answer:
Chemical uncoupling is a regulation mechanism that prevents ATP formation during normal electron transport chain operation. Uncouplers like 2,4-dinitrophenol and dicumarol disrupt the coupling of ETC and ATP synthase. Examples of chemical inhibitors include antimycin-A, amytal, cyanide, carbon monoxide, and H₂S gas.
Step-by-step explanation:
Chemical uncoupling is a regulation mechanism that prevents oxidative phosphorylation (formation of ATP) while the electron transport chain (ETC) is normally operating. Uncouplers such as 2,4-dinitrophenol and dicumarol disrupt the coupling of ETC and ATP synthase, causing all energy released during the electron transport process to become heat energy instead of ATP production. Examples of chemical inhibitors of OxPhos include antimycin-A, amytal, cyanide, carbon monoxide, and H₂S gas. On the other hand, activators and antioxidants are not usually associated with OxPhos regulation, while steroids are not typically mentioned in the context of OxPhos regulation either.