Final answer:
The liver is not a primary target site for vitamin D signals; it is involved in the metabolism and activation of vitamin D. The primary target sites are the intestines, kidneys, and bones.
Step-by-step explanation:
The primary target sites for vitamin D signals are the intestines, kidneys, and bones.
Vitamin D is synthesized in the skin and then transported to the liver via the bloodstream where it is converted to 25(OH)D (calcidiol), the major form of vitamin D circulating in the blood.
However, the liver is not considered a primary target site for vitamin D signals; rather, it plays a crucial role in the metabolism and activation of vitamin D.
Therefore, the correct answer to the question is D) Liver, as it is not a primary target site for vitamin D signals.