Final answer:
President Andrew Jackson enforced the Indian Removal Act against a Supreme Court decision, resulting in the forced relocation of the Five Civilized Tribes on the Trail of Tears.
Step-by-step explanation:
President Andrew Jackson and the Indian Removal Act, During his presidency, Andrew Jackson defied the U.S. Supreme Court's decision in the Worcester v. Georgia case in favor of Native American rights. In 1838, acting against this ruling, Jackson sent the U.S. Army to forcibly relocate Native American tribes, an event that came to be known as the Trail of Tears.
The operation primarily affected the Five Civilized Tribes, who were removed from their homelands in the southeastern United States to designated Indian Territory, now known as Oklahoma.
This tragic forced migration resulted from Jackson's support of the 1830 Indian Removal Act and stands as a dark chapter in American history, representing a significant abuse of presidential power and a direct assault on the sovereignty of Native American nations.