Final answer:
The nurse should advise the patient to mix cholestyramine powder thoroughly with a small amount of liquid first, stir vigorously, let it sit for a moment, and seek further advice if clumping continues.
Step-by-step explanation:
The nurse should suggest that the patient attempts to mix the cholestyramine (Questran) powder with a non-carbonated beverage or mix it more thoroughly. It often helps to mix the powder with a small amount of liquid first to form a paste before adding the rest of the liquid. Additionally, stirring the mixture vigorously and allowing it to sit for a few minutes after initial mixing can help reduce clumping. If the problem persists, the patient should be advised to contact their healthcare provider for further instructions or to discuss alternative medications or formulations.