Final answer:
Localized hypoplastic enamel on a single tooth in a child is most likely the result of a high fever during a disease like measles at a critical period of tooth development, rather than systemic deficiencies of nutrients such as vitamin D or calcium.
Step-by-step explanation:
A 15-year-old with hypoplastic enamel on tooth 1.5, with all other teeth appearing normal, was most likely affected by a high fever during a childhood illness such as measles at age 3. This hypoplasia is not due to a generalized deficiency like vitamin D or calcium deficiency that would typically have a more systemic impact causing rickets or generalized enamel defects. Instead, the specific and localized nature of the enamel hypoplasia on tooth 1.5 suggests a disruptive event such as high fever during the development of that tooth.