Final answer:
In a mixed dentition, a posterior cross-bite with a midline discrepancy requires immediate treatment, while other conditions like a maxillary midline diastema, crowding of incisors, or an end-to-end molar relationship are less urgent.
Step-by-step explanation:
In the mixed dentition, posterior cross-bite with a midline discrepancy should be treated immediately. A maxillary midline diastema and crowding of maxillary and mandibular incisors, while potentially concerning, generally do not require immediate treatment as these conditions may self-correct as the patient grows and their permanent teeth come in.
An end-to-end molar relationship also typically does not require immediate attention. However, a posterior cross-bite can lead to problems with jaw growth and occlusal function if not addressed promptly.