Final answer:
Nifedipine is the drug among those listed that may cause generalized enlargement of the interdental papillae, a condition also known as gingival hyperplasia.
Step-by-step explanation:
Among the drugs listed, Nifedipine is known to potentially cause a side effect of generalized enlargement of the interdental papillae. This condition is part of a group of symptoms known as gingival hyperplasia or gingival overgrowth. Nifedipine is a calcium channel blocker used primarily for the treatment of hypertension and angina pectoris.
Digitalis, Captopril, and Propranolol are not typically associated with this side effect. Digitalis is used for heart conditions, captopril for hypertension and heart failure, and propranolol is a beta-blocker used for various cardiovascular issues but not known to cause gingival enlargement.