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Step 8 - Ca+ influx causes Myosin & Actin to bind

User Vovanium
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Final answer:

Calcium ions binding to troponin lead to the exposure of myosin-binding sites on actin filaments, allowing muscle contraction through actin and myosin cross-bridge formation.

Step-by-step explanation:

When calcium ions (Ca2+) bind to troponin, this triggers a conformational change that moves tropomyosin away from the myosin-binding sites on actin filaments.

Once these sites are exposed, the myosin heads can bind to them, forming cross-bridges between the actin and myosin microfilaments, leading to muscle contraction.

In essence, Ca2+ influx is pivotal for actin and myosin interaction, which is a fundamental aspect of the muscle contraction cycle in striated muscles, including both skeletal and cardiac muscles, as well as a different role in smooth muscle contraction.

User DLR
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