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CNS: CMRO2 decreased 25%

EEG changes are similar during anaesthesia with either xenon or nitrous oxide, exhibiting attenuation of α waves at lower concentrations, with the appearance of θ and δ wave activity at higher concentrations
increased CBF --> implications for ICP
redistribution of blood flow --> from gray to white matter.
Autoregulation and CO2 reactivity preserved
Associated with nausea and vomiting

1 Answer

3 votes

Final answer:

The question relates to the effects of general anesthetics on the CNS, particularly xenon and nitrous oxide, and their effect on CMRO2, EEG patterns, CBF, ICP, and blood flow redistribution, while preserving autoregulation and CO2 reactivity.

Step-by-step explanation:

The student's question is centered around the effects of general anesthetics like xenon and nitrous oxide on the central nervous system (CNS) and its physiology, including changes in cerebral metabolic rate of oxygen (CMRO2), electroencephalogram (EEG) patterns, cerebral blood flow (CBF), intracranial pressure (ICP), and blood flow redistribution. General anesthetics induce a state of anesthesia characterized by a reversible loss of consciousness, analgesia, amnesia, immobility, and decreased autonomic responsiveness to noxious stimuli. Specific to the question, xenon and nitrous oxide can cause a decrease in CMRO2 by 25%, attenuation of α waves, and the appearance of θ and δ wave activity at higher concentrations. This can lead to increased CBF, which has implications for ICP, and redistribution of blood flow from gray to white matter. Despite these changes, autoregulation and CO2 reactivity of the brain's blood vessels are preserved. However, these anesthetics can also be associated with post-operative nausea and vomiting.

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