Final answer:
Direct acting drugs with poor absorption must be applied topically to the affected area.
Step-by-step explanation:
Direct acting drugs that have poor absorption must be applied topically instead of being taken orally.
For example, some antifungals and antibiotics like bacitracin and polymyxin are available as topical preparations for treating superficial skin infections.
This route of administration allows the drug to be applied directly to the affected area, bypassing the need for absorption through the gastrointestinal tract.