Final Answer:
CD05c Thiazide diuretics is Decreased efficacy in sodium depletion. The correct option is B. Decreased efficacy in sodium depletion.
Step-by-step explanation:
Decreased efficacy in sodium depletion (Option B): Thiazide diuretics, unlike loop diuretics such as frusemide, exhibit reduced efficacy in situations of sodium depletion. Thiazides primarily act on the distal convoluted tubule, and their effectiveness diminishes when sodium depletion is prominent.
Sodium depletion refers to a situation where the body experiences a shortage of sodium, an essential electrolyte. The statement suggests that there is a decrease in efficacy under conditions of sodium depletion.
Decreased efficacy implies that the normal functioning or effectiveness of a process or system is diminished. In the context of sodium depletion, this could refer to the body's ability to maintain proper fluid balance, regulate blood pressure, or support nerve and muscle function.
Sodium is a crucial electrolyte that plays a vital role in maintaining osmotic balance, blood pressure regulation, and nerve impulse transmission. When sodium levels are depleted, these physiological processes can be compromised, leading to a reduction in efficacy. The correct option is B. Decreased efficacy in sodium depletion.