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Antihypertensive, Diuretic, IHD

CD01 [Mar96] [Mar98] [Mar99] [Jul01] Milrinone:
A. Decreases pulmonary vascular resistance
B. Increases systemic vascular resistance
C. Is poorly absorbed when given orally
D. Chronic use causes thrombocytopaenia
E. Not effective orally

1 Answer

3 votes

Final answer:

Milrinone helps lower blood pressure by acting as a powerful generalized vasodilator and promotes diuresis by inhibiting sodium and chloride reabsorption in the loop of Henle.

Step-by-step explanation:

Diuretic and Vasodilator Effects on Blood Pressure

The student's question is centered on the pharmacological effects of certain drugs that manage hypertension. Specifically, Milrinone is mentioned along with characteristics associated with antihypertensive and diuretic medication.

Diuretics are a class of drugs that promote diuresis, the increased production of urine. They act by inhibiting the reabsorption of sodium (Na+) and chloride (Cl-) ions in the loop of Henle within the kidneys, which consequently decreases sodium reabsorption. This process also leads to a decrease in blood volume and pressure due to the loss of fluid volume from the kidneys.

Moreover, Milrinone is known for its ability to decrease pulmonary vascular resistance due to its properties as a powerful generalized vasodilator. It has the additional effect of reducing the systemic vascular resistance, which further helps in lowering blood pressure.

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