Final answer:
Irreversible cardiomyopathy can be caused by drugs that have dose-dependent cardiac toxicity, such as doxorubicin and cyclophosphamide.
Step-by-step explanation:
Irreversible cardiomyopathy can be caused by several factors. One of them is doxorubicin, which belongs to a class of drugs called anthracyclines. Anthracyclines, such as doxorubicin, can cause dose-dependent cardiac toxicity. This means that the risk of cardiac toxicity increases with higher doses of the drug.
Another drug that can cause dose-dependent cardiac toxicity is cyclophosphamide, which is also an anthracycline. Like doxorubicin, higher doses of cyclophosphamide are associated with a higher risk of cardiac toxicity.
Therefore, the correct answer to the question is C. Danorubicin and E. Cyclophosphamide.