Final answer:
A decrease in renal function might be expected with medications like Gentamicin, Cisplatin, Busulphan, and Methotrexate, as they all have potential nephrotoxic effects. The correct option out of the choices given is E. All of the above, since all listed drugs can negatively impact kidney function.
Step-by-step explanation:
A decrease in renal function might be expected with several drugs due to their nephrotoxic effects. Among the options provided:
- Gentamicin is an aminoglycoside antibiotic known for its potential to cause kidney damage, especially with prolonged use or in higher doses.
- Cisplatin (Platinol®) is a chemotherapy medication that has nephrotoxicity as one of its side effects, often due to oxidative damage within the kidneys.
- Busulphan is less commonly associated with direct nephrotoxicity, but it can contribute to renal issues in the context of bone marrow transplantation and when used in conjunction with other cytotoxic agents.
- Methotrexate (Abitrexate®), which is also used in chemotherapy, can cause kidney damage due to precipitation of the drug and its metabolites in the renal tubules, especially at high doses.
Therefore, the correct answer to the question of which drug might expect a decrease in renal function is E. All of the above.