Final answer:
Perindopril is contraindicated in pre-eclampsia because it is an ACE inhibitor, which is associated with a risk of congenital defects and fetal harm when used during pregnancy. Alternatives like Methyldopa, Labetalol, and Hydralazine are generally considered safer for managing hypertension in pregnant women.
Step-by-step explanation:
The drug that is contraindicated in pre-eclampsia is Perindopril. Perindopril is an Angiotensin-Converting Enzyme (ACE) inhibitor, which is generally contraindicated in pregnancy due to the risk of causing fetal harm, especially in the second and third trimesters. Pre-eclampsia is a condition characterized by high blood pressure and often a significant amount of protein in the urine. The management of pre-eclampsia involves close monitoring and medications that can safely lower blood pressure without harming the fetus. Drugs such as Methyldopa, Labetalol, and Hydralazine are typically considered safer alternatives during pregnancy to control hypertension. Clonidine is also used but is generally not the first choice. Importantly, ACE inhibitors like Perindopril are avoided in pre-eclampsia due to their association with congenital defects and other adverse effects on the fetus.