Final answer:
Thrombocytopaenia, a condition marked by a low platelet count, can be caused by several drugs including Busulphan, Cis-platin, and Methotrexate, as they may disrupt platelet production in the bone marrow. Thus, the answer to which one of the substances can lead to thrombocytopaenia as a side effect is D. All of the above.
Step-by-step explanation:
Thrombocytopaenia is a condition where there is an abnormally low number of platelets in the blood, which can result in abnormal bleeding. Among the drugs listed, Busulphan, Cis-platin, and Methotrexate can all potentially cause thrombocytopaenia as a side effect. Drugs such as Antimetabolites, including Methotrexate, and other chemotherapy agents like Busulphan and Cis-platin, can affect the bone marrow's ability to produce platelets, leading to thrombocytopaenia.
Platelets, which are critical for blood clotting, arise from megakaryocytes in the bone marrow. When drugs that are toxic to the bone marrow are used, as in the case of chemotherapy for cancer, thrombocytopaenia can be a serious and potentially life-threatening complication. Due to this suppression of platelet production, D. All of the above is the correct answer to the question of thrombocytopaenia being a side-effect of which one of the following substances.