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What does Caspase-1 reqruitment require?

User ATV
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Final answer:

The recruitment of Caspase-1 requires the exit of cytochrome C, binding to adaptor proteins, and procaspase activation.

Step-by-step explanation:

Recruitment of Caspase-1 requires several steps. Firstly, cytochrome C molecules exit the intermembrane space of mitochondria and bind to adaptor proteins in the cytosol. This forms a cytochrome C-adaptor complex. Then, procaspase, a biologically inactive form of caspase, binds to the cytochrome C-adaptor complex. This binding causes an allosteric change in procaspase, releasing an active caspase-1.

Caspase-1 is a proteolytic enzyme that starts the auto-digestion of the cell. It plays a role in the process of apoptosis, where active caspases digest cellular proteins. In summary, Caspase-1 recruitment requires the exit of cytochrome C, binding to adaptor proteins, and procaspase activation.

User Rolgalan
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